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81.
82.
Robyn K Fuchs Matt R Allen Meghan E Ruppel Tamim Diab Roger J Phipps Lisa M Miller David B Burr 《Matrix biology》2008,27(1):34-41
At the tissue level it is well established that the rate of remodeling is related to the degree of mineralization. However, it is unknown how long it takes for an individual bone structural unit (BSU) to become fully mineralized during secondary mineralization. Using synchrotron Fourier transform infrared microspectroscopy (FTIRM) we examined the time required for newly formed bone matrix to reach a physiological mineralization limit. Twenty-six, four-month old female New Zealand white rabbits were administered up to four different fluorochrome labels at specific time points to evaluate the chemical composition of labeled osteons from the tibial diaphysis that had mineralized for 1, 8, 18, 35, 70, 105, 140, 175, 210, 245, 280, 315, 350, and 385 days. Interstitial bone from 505 day old rabbits was used as a reference value for the physiological limit to which bone mineralizes. Using synchrotron FTIRM, area integrations were carried out on protein (Amide I: 1688-1623 cm(-1)), carbonate (v(2)CO(3)(2-): 905-825 cm(-1)), and phosphate (v(4)PO(4)(3-): 650-500 cm(-1)) IR bands. IR spectral data are presented as ratios of phosphate/protein (overall matrix mineralization) and carbonate/protein. The rate of mineralization of osteonal bone proceeded rapidly between day 1 and 18, reaching 67% of interstitial bone levels. This was followed by a slower, more progressive accumulation of mineral up to day 350. By 350 days the rate of increase plateaued. The ratio of carbonate/protein also increased rapidly during the first 18 days, reaching 73% of interstitial bone levels. The ratio of carbonate/protein plateaued by day 315, reaching levels not significantly different to interstitial bone levels. In conclusion, our data demonstrate that bone accumulates mineral rapidly during the first 18 days (primary mineralization), followed by a more gradual increase in the accumulation of mineral (secondary mineralization) which we found to be completed in 350 days. 相似文献
83.
84.
Iman Fathy Abou-El-Naga Hayam Abd El-Monem Sadaka Eglal Ibrahim Amer Iman Hassan Diab Safaa Ibrahim Abd El-Halim Khedr 《Memórias do Instituto Oswaldo Cruz》2015,110(5):585-595
Of the approximately 34 identified Biomphalaria
species,Biomphalaria alexandrina represents the
intermediate host of Schistosoma mansoni in Egypt. Using
parasitological and SOD1 enzyme assay, this study aimed to elucidate the impact of
the age of B. alexandrina snails on their genetic variability and
internal defence against S. mansoni infection. Susceptible and
resistant snails were reared individually for self-reproduction; four subgroups of
their progeny were used in experiment. The young susceptible subgroup showed the
highest infection rate, the shortest pre-patent period, the highest total cercarial
production, the highest mortality rate and the lowest SOD1 activity. Among the young
and adult susceptible subgroups, 8% and 26% were found to be resistant, indicating
the inheritance of resistance alleles from parents. The adult resistant subgroup,
however, contained only resistant snails and showed the highest enzyme activity. The
complex interaction between snail age, genetic background and internal defence
resulted in great variability in compatibility patterns, with the highest significant
difference between young susceptible and adult resistant snails. The results
demonstrate that resistance alleles function to a greater degree in adults, with
higher SOD1 activity and provide potential implications for Biomphalaria
control. The identification of the most susceptible snail age enables
determination of the best timing for applying molluscicides. Moreover, adult
resistant snails could be beneficial in biological snail control. 相似文献
85.
Diab Kawthar A. Fahmy Maha A. Hassan Emad M. El-Toumy Sayed A. 《Molecular biology reports》2022,49(9):8439-8448
Molecular Biology Reports - In this study, two main research objectives were examined: (1) the cytotoxic and anticancer activities of the aqueous methanol extract from Acacia nilotica flowers on... 相似文献
86.
Diab Kawthar A. Fahmy Maha A. Hassan Emad M. Hassan Zeinab M. Omara Enayat A. Abdel-Samie Negm S. 《Molecular biology reports》2020,47(3):1733-1749
Molecular Biology Reports - Black mulberry (Morus nigra) leaves is broadly used in traditional medicine worldwide. However, there are no scientific reports regarding testicular protection,... 相似文献